How Retatrutide + MOTS-c Can Support Metabolic Health, Body Composition, and Everyday Energy
When most programs focus on “eat less, move more,” results often stall—especially if appetite, insulin sensitivity, and cellular energy aren’t addressed together. INOV8 R3ta Plus 1 is designed for that intersection: pairing Retatrutide (GLP-1/GIP/Glucagon triple-agonist) for powerful appetite and glycemic support with MOTS-c, a mitochondrial peptide linked to AMPK activation, insulin sensitivity, and endurance. The result is a hybrid approach aimed at body composition + metabolic longevity.
What Makes R3ta Plus 1 Different?
Dual-pathway design
- Retatrutide: Supports appetite control, improved glycemic dynamics, and fat-loss signaling.
- MOTS-c: Targets cellular metabolism and mitochondrial function, promoting insulin sensitivity, metabolic flexibility, and performance capacity.
Ready-to-use precision
- Pre-mixed, click-dosed pen minimizes prep and guesswork for consistent administration.
Real-world practicality
- Morning/early afternoon dosing aligns with daytime appetite control and activity.
What’s in Each Pen?
- Retatrutide: 30 mg
- MOTS-c: 50 mg
- Total volume: 2.6 mL per pen (240 clicks)
Per click (≈0.0108 mL):
- Retatrutide ~0.125 mg
- MOTS-c ~0.208 mg
Directions
- Frequency: Twice weekly (every 3–4 days)
- Method: Subcutaneous injection; rotate sites; sterile single-use needles
- Storage: Refrigerate (2–8 °C), protect from light
Suggested 12-Week Protocol
| Weeks | Clicks/Dose | Retatrutide | MOTS-c | Focus |
|---|---|---|---|---|
| 1–2 | 10 | 1.25 mg | 2.08 mg | Gentle start, appetite reset |
| 3–4 | 14 | 1.75 mg | 2.9 mg | Metabolic activation |
| 5–8 | 20 | 2.5 mg | 4.2 mg | Weight loss acceleration, insulin support |
| 9–12 | 28 | 3.5 mg | 5.8 mg | Peak effect: fat loss + mitochondrial energy |
Pen longevity (240 clicks):
10 clicks = 12 weeks • 14 clicks ≈ 8.5 weeks • 20 clicks = 6 weeks • 28 clicks = 4 weeks
Use only under guidance from a qualified healthcare professional. Biomarker monitoring is advised (glucose, lipids, IGF-1, liver/kidney markers).
How the Pairing Works (In Plain English)
1) Manage appetite and glucose swings (Retatrutide)
Supports satiety and steadier glycemic control—making a sustainable calorie deficit and consistent nutrition easier to maintain.
2) Support cellular energy and insulin sensitivity (MOTS-c)
By engaging AMPK-related pathways, MOTS-c promotes mitochondrial efficiency, exercise capacity, and glucose handling—useful for training quality and day-to-day vitality.
3) Protect the hard-earned muscle
With better appetite control and training-friendly energy, it’s easier to hit protein targets and lift consistently—key for preserving lean mass while cutting fat.
A Weekly Rhythm That Reinforces Results
- Dose Days (e.g., Mon/Thu mornings):
Light movement within 2–4 hours (walks, zone-2 cardio). Protein-forward meals (25–40 g per meal). Hydrate and aim for 7–9 hours of sleep. - Training (3–4x/week):
Prioritize compound lifts to maintain/build lean mass; keep daily steps 7–12k for metabolic flexibility. - Nutrition:
Modest calorie deficit, 1.6–2.2 g/kg/day protein, 25–35 g fiber, mostly minimally processed foods. Consider a consistent eating window that fits your lifestyle.
Who Might Consider R3ta Plus 1?
- Adults looking for weight-loss with performance in mind
- Individuals wanting appetite control + insulin support while preserving training quality
- Those interested in metabolic health and longevity rather than short-term fixes
Not for individuals under 18, during pregnancy, with active cancers, or severe liver/kidney impairment. Discuss medical history and medications with your clinician. Mild GI effects can occur early (common with GLP-1s).
Quality and Safety You Can Verify
- GMP-certified sterile production and fill-finish
- HPLC/MS verification of raw peptides
- Batch-coded pens with traceability and expiry
- Cold-chain shipping to maintain peptide stability
Weight loss is only one part of the story. By combining Retatrutide for appetite/metabolic control with MOTS-c for cellular energy and insulin sensitivity, INOV8 R3ta Plus 1 supports a smarter path to body composition, metabolic flexibility, and long-term vitality—in a ready-to-use, precision-dosed format.